1,3-Dichloropropane Property

Melting point:

−99 °C(lit.)

Boiling point:

120-122 °C(lit.)

Density 

1.19 g/mL at 25 °C(lit.)

vapor pressure 

24-24.265hPa at 20-25℃

refractive index 

n20/D 1.448(lit.)

Flash point:

90 °F

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Liquid

color 

Clear colorless

Water Solubility 

0.8 g/L (20 ºC)

BRN 

505960

Dielectric constant

9.5099999999999998

InChIKey

YHRUOJUYPBUZOS-UHFFFAOYSA-N

LogP

2 at 25℃ and pH7

CAS DataBase Reference

142-28-9(CAS DataBase Reference)

NIST Chemistry Reference

Propane, 1,3-dichloro-(142-28-9)

EPA Substance Registry System

1,3-Dichloropropane (142-28-9)

Safety

Hazard Codes 

F,Xn,T,Xi

Risk Statements 

11-20-20/22-52/53-36/37/38-39/23/24/25-23/24/25-36-20/21/22

Safety Statements 

9-16-29-33-24-61-26-45-36/37-7

RIDADR 

UN 1993 3/PG 2

WGK Germany 

2

RTECS 

TX9660000

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29031990

Hazardous Substances Data

142-28-9(Hazardous Substances Data)

Toxicity

dog,LDLo,oral,3gm/kg (3000mg/kg),LIVER: OTHER CHANGESLUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMABLOOD: HEMORRHAGE,American Journal of Hygiene. Vol. 16, Pg. 325, 1932.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1,3-Dichloropropane Chemical Properties,Usage,Production

Chemical Properties

1,3-Dichloropropene occurs as a clear colourless liquid with a sweet chloroform-like odor. It is soluble in alcohol and ether, dissolves in water (0.27g/100ml). The half-life of 1,3-dichloropropene in ambient air may range from 7 to 50 hours.

Uses

1,3-Dichloropropane is used as an intermediate in organic synthesis. It is also used as solvent, detergent and chromatographic analysis. Further, it is used to prepare 3,7-dithia-nonanedioic acid by reacting with mercaptoacetic acid.

Definition

ChEBI: 1,3-dichloropropane is a chloroalkane that is propane in which a hydrogen from each of the terminal methyl groups has been replaced by a chlorine. It has a role as an environmental contaminant and a nematicide. It is a chloroalkane and a chlorohydrocarbon.

Preparation

1,3-Dichloropropane is obtained by the action of propylene glycol with hydrochloric acid.
1,3-Dichloropropane synthesis: A process for the preparation of 1,3-dichloropropane by reacting bis(3-hydroxypropyl)ether with hydrogen chloride, optionally in the presence of tertiary basic nitrogen compounds or other tertiary aliphatic bases as catalysts, distilling off the 1,3-dichloropropane and the water of reaction and working up the two phases.
Process for the preparation of 1,3-dichloropropane

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 194, 1964 DOI: 10.1021/jo01024a045

General Description

1,3-dichloropropane is a colorless watery liquid with a sweet odor. Sinks in water. Produces irritating vapor. (USCG, 1999)

Air & Water Reactions

Highly flammable.

Reactivity Profile

Halogenated aliphatic compounds, such as 1,3-Dichloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Health Hazard

INHALATION: May cause some central nervous system depression. EYES: May cause some pain and irritation. SKIN: Mild irritation.

Safety Profile

Moderately toxic by ingestion. Mutation data reported. A very dangerous fire hazard when exposed to heat or flame. When heated to decomposition it emits highly toxic fumes of Cl and phosgene. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and PROPYLENE DICHLORIDE.